Latest cases of high pressure technologies introduced into fields of medicine and medical care

Use of high pressure in the latest therapy for giant congenital melanocytic nevi

The clinical trial of skin regeneration treatment for giant congenital melanocytic nevi using high pressure has started for the first time in the world

Participating organizations

  • Kansai Medical University, department of plastic and reconstructive surgery
    • * Dr. Naoki Morimoto (associate professor, team leader of this project), et al.
  • National Cerebral and Cardiovascular Center
    • * Dr. Tetsuji Yamaoka (director of biomedical engineering department), et al.
  • Graduate school of Medicine Kyoto University, department of plastic
    and reconstructive surgery
  • Kyoto University Hospital, Institute for Advancement of Clinical and Translational Science, department of experimental therapeutics
  • Osaka Institute of Technology, department of biomedical engineering

  • Dr. Morimoto, associate professor
    of Kansai Medical University

  • Dr. Yamaoka, director of biomedical engineering dept. of National Cerebral and Cardiovascular Center

Summary of the therapy

(1) The research team started a clinical trial of the skin regeneration treatment using high pressure for giant congenital melanocytic nevi, for the first time in the world, in Kansai Medical University Hospital in March 2016.
 
(2) Nevus tissue cut off from a patient’s skin was treated with high pressure of 200 MPa for 10 minutes, and then returned to the original position. The high-pressure treatment completely destructed the tumor cell in the dermis without impairing the dermal functions. The skin structure was reconstructed using the patient’s own cell and tissue, i.e., the dermis treated with high pressure and the autologous cultured epidermis.

 
(3) This therapy is able to ensure the high degree of safety because it used the high-pressure technology, a physical method, not using any chemical involving the risk of residual toxicity.

 
(4) The high-pressure treatment for cell destruction shows great promise as a new tissue-regeneration method applicable to malignant tumors of the skin and other tissues in future.

Flow of the therapy

Novel treatment for giant congenital melanocytic nevi by using inactivated autologous dermis and cultured epidermal autograft (First-in-man clinical trial)

Treating giant nevus tissue with hydrostatic pressure before implantation
Medical team including Kansai Medical University started the clinical trial for the first time in the world (in japanese)

  • Published on

    Dec. 11, 2015 (2:17)

  • Source:

    Jiji Press Ltd.