What is "High-Pressure treatment"?
Latest cases of high pressure technologies introduced into fields of medicine and medical care
Use of high pressure in the latest therapy for giant congenital melanocytic nevi
The clinical trial of skin regeneration treatment for giant congenital melanocytic nevi using high pressure has started for the first time in the world
- Kansai Medical University, department of plastic and reconstructive surgery
- * Dr. Naoki Morimoto (associate professor, team leader of this project), et al.
- National Cerebral and Cardiovascular Center
- * Dr. Tetsuji Yamaoka (director of biomedical engineering department), et al.
- Graduate school of Medicine Kyoto University, department of plastic
and reconstructive surgery
- Kyoto University Hospital, Institute for Advancement of Clinical and Translational Science, department of experimental therapeutics
- Osaka Institute of Technology, department of biomedical engineering
Dr. Morimoto, associate professor
of Kansai Medical University
Dr. Yamaoka, director of biomedical engineering dept. of National Cerebral and Cardiovascular Center
Summary of the therapy
(1) The research team started a clinical trial of the skin regeneration treatment using high pressure for giant congenital melanocytic nevi, for the first time in the world, in Kansai Medical University Hospital in March 2016.
(2) Nevus tissue cut off from a patient’s skin was treated with high pressure of 200 MPa for 10 minutes, and then returned to the original position. The high-pressure treatment completely destructed the tumor cell in the dermis without impairing the dermal functions. The skin structure was reconstructed using the patient’s own cell and tissue, i.e., the dermis treated with high pressure and the autologous cultured epidermis.
(3) This therapy is able to ensure the high degree of safety because it used the high-pressure technology, a physical method, not using any chemical involving the risk of residual toxicity.
(4) The high-pressure treatment for cell destruction shows great promise as a new tissue-regeneration method applicable to malignant tumors of the skin and other tissues in future.
Flow of the therapy
Novel treatment for giant congenital melanocytic nevi by using inactivated autologous dermis and cultured epidermal autograft (First-in-man clinical trial)
Dec. 11, 2015 (2:17)
Jiji Press Ltd.